508 research outputs found
Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium.
Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-κB. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were injected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-κB p50, IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-κB expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo
Transport or Store? Synthesizing Flow-based Microfluidic Biochips using Distributed Channel Storage
Flow-based microfluidic biochips have attracted much atten- tion in the EDA
community due to their miniaturized size and execution efficiency. Previous
research, however, still follows the traditional computing model with a
dedicated storage unit, which actually becomes a bottleneck of the performance
of bio- chips. In this paper, we propose the first architectural synthe- sis
framework considering distributed storage constructed tem- porarily from
transportation channels to cache fluid samples. Since distributed storage can
be accessed more efficiently than a dedicated storage unit and channels can
switch between the roles of transportation and storage easily, biochips with
this dis- tributed computing architecture can achieve a higher execution
efficiency even with fewer resources. Experimental results con- firm that the
execution efficiency of a bioassay can be improved by up to 28% while the
number of valves in the biochip can be reduced effectively.Comment: ACM/IEEE Design Automation Conference (DAC), June 201
A hybrid simulated annealing for scheduling in dual-resource cellular manufacturing system considering worker movement
This paper presents a novel linear mathematical model for integrated cell formation and task scheduling in the cellular manufacturing system (CMS). It is suitable for the dual-resource constrained setting, such as garment process, component assembly, and electronics manufacturing. The model can handle the manufacturing project composing of some tasks with precedence constraints. It provides a method to assign the multi-skilled workers to appropriate machines. The workers are allowed to move among the machines such that the processing time of tasks might be reduced. A hybrid simulated annealing (HSA) is proposed to minimize the makespan of manufacturing project in the CMS. The approach combines the priority rule based heuristic algorithm (PRBHA) and revised forward recursion algorithm (RFRA) with conventional simulated annealing (SA). The result of extensive numerical experiments shows that the proposed HSA outperforms the conventional SA accurately and efficiently
Optical rotation of heavy hole spins by non-Abelian geometrical means
A non-Abelian geometric method is proposed for rotating of heavy hole spins
in a singly positive charged quantum dot in Voigt geometry. The key ingredient
is the delay-dependent non-Abelian geometric phase, which is produced by the
nonadiabatic transition between the two degenerate dark states. We demonstrate,
by controlling the pump, the Stokes and the driving fields, that the rotations
about - and -axes with arbitrary angles can be realized with high
fidelity. Fast initialization and heavy hole spin state readout are also
possible.Comment: 7 pages, 6 figure
Testing Microfluidic Fully Programmable Valve Arrays (FPVAs)
Fully Programmable Valve Array (FPVA) has emerged as a new architecture for
the next-generation flow-based microfluidic biochips. This 2D-array consists of
regularly-arranged valves, which can be dynamically configured by users to
realize microfluidic devices of different shapes and sizes as well as
interconnections. Additionally, the regularity of the underlying structure
renders FPVAs easier to integrate on a tiny chip. However, these arrays may
suffer from various manufacturing defects such as blockage and leakage in
control and flow channels. Unfortunately, no efficient method is yet known for
testing such a general-purpose architecture. In this paper, we present a novel
formulation using the concept of flow paths and cut-sets, and describe an
ILP-based hierarchical strategy for generating compact test sets that can
detect multiple faults in FPVAs. Simulation results demonstrate the efficacy of
the proposed method in detecting manufacturing faults with only a small number
of test vectors.Comment: Design, Automation and Test in Europe (DATE), March 201
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